Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Oral Epithelium
DISEASE(S): Oral Cavity Cancer
SUBMITTER: Aditi Chatterjee
LAB HEAD: Aditi Chatterjee
PROVIDER: PXD007127 | Pride | 2019-11-08
REPOSITORIES: Pride
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Cancer biology & therapy 20180529 9
Tobacco usage is a known risk factor associated with development of oral cancer. It is mainly consumed in two different forms (smoking and chewing) that vary in their composition and methods of intake. Despite being the leading cause of oral cancer, molecular alterations induced by tobacco are poorly understood. We therefore sought to investigate the adverse effects of cigarette smoke/chewing tobacco exposure in oral keratinocytes (OKF6/TERT1). OKF6/TERT1 cells acquired oncogenic phenotype after ...[more]