Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
DISEASE(S): Huntington Disease
SUBMITTER: Niels Henning Skotte
LAB HEAD: Michael L. Nielsen
PROVIDER: PXD008099 | Pride | 2019-01-11
REPOSITORIES: Pride
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Cell reports 20180501 7
Huntington's disease is a fatal neurodegenerative disease, where dysfunction and loss of striatal and cortical neurons are central to the pathogenesis of the disease. Here, we integrated quantitative studies to investigate the underlying mechanisms behind HD pathology in a systems-wide manner. To this end, we used state-of-the-art mass spectrometry to establish a spatial brain proteome from late-stage R6/2 mice and compared this with wild-type littermates. We observed altered expression of prote ...[more]