Proteomics

Dataset Information

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C1R.B*58:01 MHC class I immunopeptidome LC-MSMS

ABSTRACT: Characterisation of peptide ligands of Major histocompatibility class (MHC) I isolated by immunoaffinity purification from the C1R (Class I reduced) B-lymphoblastoid cell line, transfected with the MHC class I allele HLA-B*58:01.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Suspension Culture

SUBMITTER: Patricia Illing  

LAB HEAD: Anthony W. Purcell

PROVIDER: PXD008572 | Pride | 2018-10-24

REPOSITORIES: Pride

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Action DRS
110910_mB5801_2017uniprotPilot5.group Other
110910_mB5801ex_2017uniprotPilot5.group Other
111203_mB5801_2017uniprotPilot5.group Other
111203_mB5801ex_2017uniprotPilot5.group Other
120225_mB5801_2017uniprotPilot5.group Other
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Publications

Immunophenotypic differences between closely related human leukocyte antigen (HLA) alleles have been associated with divergent clinical outcomes in infection, autoimmunity, transplantation and drug hypersensitivity. Here we explore the impact of micropolymorphism on peptide antigen presentation by three closely related HLA molecules, HLA-B*57:01, HLA-B*57:03 and HLA-B*58:01, that are differentially associated with the HIV elite controller phenotype and adverse drug reactions. For each allotype,  ...[more]

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