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The role of cadaverine synthesis on pneumococcal capsule and protein expression.

ABSTRACT: S. pneumoniae TIGR4 wild type strain and lysine decarboxylase deficient strain were cultured in quadruplicate in THY. Proteins were isolated, quantified, trypsin digested and analyzed by 1D LC ESI MS/MS.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Streptococcus Pneumoniae Tigr4

SUBMITTER: Caleb Benson

LAB HEAD: Bindu Nanduri

PROVIDER: PXD008621 | Pride | 2018-01-24

REPOSITORIES: Pride

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			Action	DRS
	AS_216429_1_Dcad.raw	Raw
	AS_216429_1_TiGR4.raw	Raw
	AS_216429_2_Dcad.raw	Raw
	AS_216429_2_TiGR4.raw	Raw
	AS_216429_3_Dcad.raw	Raw

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Publications

The Role of Cadaverine Synthesis on Pneumococcal Capsule and Protein Expression.

Nakamya Mary F MF Ayoola Moses B MB Park Seongbin S Shack Leslie A LA Swiatlo Edwin E Nanduri Bindu B

Medical sciences (Basel, Switzerland) 20180119 1

Invasive infections caused by <i>Streptococcus pneumoniae</i>, a commensal in the nasopharynx, pose significant risk to human health. Limited serotype coverage by the available polysaccharide-based conjugate vaccines coupled with increasing incidence of antibiotic resistance complicates therapeutic strategies. Bacterial physiology and metabolism that allows pathogens to adapt to the host are a promising avenue for the discovery of novel therapeutics. Intracellular polyamine concentrations are ti ...[more]

PMID: 29351189

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