Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Drosophila Melanogaster (fruit Fly)
SUBMITTER: Alexander Leitner
LAB HEAD: Alexander Leitner
PROVIDER: PXD009526 | Pride | 2018-06-11
REPOSITORIES: Pride
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aleitner_D1604_136.raw | Raw | |||
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aleitner_D1604_138.raw | Raw | |||
aleitner_D1607_221.raw | Raw |
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Proceedings of the National Academy of Sciences of the United States of America 20180613 26
In eukaryotes, the heterohexameric origin recognition complex (ORC) coordinates replication onset by facilitating the recruitment and loading of the minichromosome maintenance 2-7 (Mcm2-7) replicative helicase onto DNA to license origins. <i>Drosophila</i> ORC can adopt an autoinhibited configuration that is predicted to prevent Mcm2-7 loading; how the complex is activated and whether other ORC homologs can assume this state are not known. Using chemical cross-linking and mass spectrometry, bioc ...[more]