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A carcinogenic trigger to study the function of tumor suppressor genes in Schmidtea mediterranea

ABSTRACT: Combining the exposure to the human carcinogen cadmium to in silico and proteomic top-down approaches the conserved function of two novel tumor suppressor genes in planarians were disclosed.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Schmidtea Mediterranea (freshwater Planarian Flatworm)

SUBMITTER: Jean-Paul Noben

LAB HEAD: Karen Smeets

PROVIDER: PXD009852 | Pride | 2019-11-12

REPOSITORIES: Pride

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			Action	DRS
	PeptideReportforSpot001tot251.xlsx	Xlsx
	Spot001.sf3	Other
	Spot002.sf3	Other
	Spot003.sf3	Other
	Spot004.sf3	Other

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A carcinogenic trigger to study the function of tumor suppressor genes in Schmidtea mediterranea.

Van Roten Andromeda A Barakat Amal Zohir Abo-Zeid AZA Wouters Annelies A Tran Thao Anh TA Mouton Stijn S Noben Jean-Paul JP Gentile Luca L Smeets Karen K

Disease models & mechanisms 20180816 9

Planarians have been long known for their regenerative ability, which hinges on pluripotency. Recently, however, the planarian model has been successfully established for routine toxicological screens aimed to assess overproliferation, mutagenicity and tumorigenesis. In this study, we focused on planarian tumor suppressor genes (TSGs) and their role during chemically induced carcinogenic stress in Schmidtea mediterranea Combining in silico and proteomic screens with exposure to hum ...[more]

PMID: 29967069

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