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Human Cerebrospinal fluid mass-spec

ABSTRACT: Cerebrospinal fluid from Alzheimer patients affects cell-mediated nerve growth factor production and cell survival in vitroCerebrospinal fluid from Alzheimer patients affects cell-mediated nerve growth factor production and cell survival in vitro

INSTRUMENT(S): 6330 Ion Trap LC/MS

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cerebrospinal Fluid

DISEASE(S): Lewy Body Dementia,Alzheimer's Disease,Memory Impairment

SUBMITTER: Homira Behbahani

LAB HEAD: Homira Behbahani

PROVIDER: PXD010230 | Pride | 2018-08-13

REPOSITORIES: Pride

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			Action	DRS
	Homira 3sep21.pride.mgf.gz	Mgf
	Homira18Oprov1.mgf	Mgf
	Homira18Oprov1.pride.mgf.gz	Mgf
	Homira18Oprov2.Aug3mgf.mgf	Mgf
	Homira18Oprov2.Aug3mgf.pride.mgf.gz	Mgf

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Publications

Cerebrospinal fluid from Alzheimer patients affects cell-mediated nerve growth factor production and cell survival in vitro.

Eriksdotter Maria M Navarro-Oviedo Manuel M Mitra Sumonto S Wahlberg Lars L Linderoth Bengt B Tjernberg Lars O LO Behbahani Homira H

Experimental cell research 20180806 1

Alzheimer's disease (AD) is characterized by early degeneration of cholinergic neurons and decreased levels of nerve growth factor (NGF). Thus, increasing the NGF levels by for instance encapsulated cell bio-delivery (ECB) is a potential treatment strategy. The results from our previous first-in-human studies on ECB of NGF to the basal forebrain cholinergic neurons were promising, but indicated some variability of long-term viability of the encapsulated cells and associated reduced NGF-release. ...[more]

PMID: 30092220

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