Proteomics

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The Synovial Fluid Proteome Differentiates between Septic and Nonseptic Articular Pathologies

ABSTRACT: Presently few studies have investigated the proteomic profile of equine synovial fluid (SF) using high mass resolution mass spectrometer and in-solution trypsin digestion and to our knowledge none have investigated protein profile changes septic SF in any species. In this study we have used mass spectrometry and label-free quantification to identify potential protein biomarkers that allow differentiation between equine articular joint pathologies, potentially aiding accurate diagnosis and enabling increased understanding of the effect of septic synovitis on the joint environment. Identification of characteristic proteomic profiles in synovial sepsis would increase the understanding of the molecular basis of the condition and also allow the identification of potential biomarkers for early diagnosis and treatment of the disease. We hypothesised that proteomic profile characteristics will distinguish septic from non-septic equine arthropathies and between the non-septic common arthropathies osteochondrosis and OA.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Equus Caballus (horse)

TISSUE(S): Synovial Tissue

SUBMITTER: Aibek Smagul  

LAB HEAD: Mandy Jayne Peffers

PROVIDER: PXD011276 | Pride | 2019-05-01

REPOSITORIES: Pride

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The synovial fluid proteome differentiates between septic and nonseptic articular pathologies.

Anderson James R JR   Smagul Aibek A   Simpson Deborah D   Clegg Peter D PD   Rubio-Martinez Luis M LM   Peffers Mandy J MJ  

Journal of proteomics 20190425

Articular conditions are common in horses and can result in loss of function, chronic pain and/or inability to work. Common conditions include osteoarthritis, osteochondrosis and synovial sepsis, which can be life-threatening, but despite the high clinical prevalence of these conditions, rapid and specific diagnosis, monitoring and prognostication remains a challenge for practicing veterinarians. Synovial fluid from a range of arthropathies was enriched for low abundance proteins using combinato  ...[more]

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