Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Erythrocyte, Blood Cell, Blood Plasma, Blood
SUBMITTER: Johan Palmfeldt
LAB HEAD: Johan Palmfeldt
PROVIDER: PXD011314 | Pride | 2019-07-31
REPOSITORIES: Pride
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1001_cs768_B_P_0-25-2.raw | Raw | |||
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1005_cs768_B_P_0-2.raw | Raw | |||
1037_cs768_B_P_5-1_redo.raw | Raw | |||
3823_SBO_0_1.raw | Raw |
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ACS chemical biology 20181203 12
Methylglyoxal (MG) is quantitatively the most important precursor to advanced glycation end-products (AGEs), and evidence is accumulating that it is also a causally linked to diabetes and aging related diseases. Living systems primarily reside on the glyoxalase system to detoxify MG into benign d-lactate. The flux to either glycation or detoxification, accordingly, is a key parameter for how well a system handles the ubiquitous glyoxal burden. Furthermore, insight into proteins and in particular ...[more]