Dataset Information

B cells sustain inflammation in human melanoma

ABSTRACT: This is the data to the melanoma-medium induction experiment. Tumor-associated and peripheral B cells from four patients were exposed to melanoma-conditioned medium (from one of the patients). This induced distinct phenotypic and functional changes in the B cells.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): B Cell

SUBMITTER: Johannes Griss

LAB HEAD: Stephan N Wagner

PROVIDER: PXD011799 | Pride | 2019-10-09

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	20170126_Lumos_RSLC2_Maurer_Hartl_UW_MFPL_shotgun_MMa_TMT2_TiO2_Fr3_MS2.mgf	Mgf
	20170126_Lumos_RSLC2_Maurer_Hartl_UW_MFPL_shotgun_MMa_TMT2_TiO2_Fr3_MS2.mgf.mzid	Mzid
	20170126_Lumos_RSLC2_Maurer_Hartl_UW_MFPL_shotgun_MMa_TMT2_TiO2_Fr3_MS2.mgf.xtandem.xml.mzid	Mzid
	20170126_Lumos_RSLC2_Maurer_Hartl_UW_MFPL_shotgun_MMa_TMT2_TiO2_Fr3_MS2.raw	Raw
	20170131_Lumos_RSLC4_Maurer_Hartl_UW_MFPL_Global_TMT_fr10_MS2.mgf	Mgf

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Publications

B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma.

Griss Johannes J Bauer Wolfgang W Wagner Christine C Simon Martin M Chen Minyi M Grabmeier-Pfistershammer Katharina K Maurer-Granofszky Margarita M Roka Florian F Penz Thomas T Bock Christoph C Zhang Gao G Herlyn Meenhard M Glatz Katharina K Läubli Heinz H Mertz Kirsten D KD Petzelbauer Peter P Wiesner Thomas T Hartl Markus M Pickl Winfried F WF Somasundaram Rajasekharan R Steinberger Peter P Wagner Stephan N SN

Nature communications 20190913 1

Tumor associated inflammation predicts response to immune checkpoint blockade in human melanoma. Current theories on regulation of inflammation center on anti-tumor T cell responses. Here we show that tumor associated B cells are vital to melanoma associated inflammation. Human B cells express pro- and anti-inflammatory factors and differentiate into plasmablast-like cells when exposed to autologous melanoma secretomes in vitro. This plasmablast-like phenotype can be reconciled in human melanoma ...[more]

PMID: 31519915

Dataset Information

B cells sustain inflammation in human melanoma

Dataset's files

Publications

B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma.

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