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Human Salivary Neutrophil Defensins (Alpha-Defensins)

ABSTRACT: In the HPLC high-resolution ESI-MS profiles of both Predominantly Antibody Deficiency syndromes subjects and healthy controls saliva samples, four proteins, with exp. monoisotopic ion [M+H]+ at 3440.54 ± 0.06 m/z, 3369.50± 0.06 m/z, 3484.51 ± 0.06 m/z and 3707.77 ± 0.06, eluting between 24.5-26.6 minutes, were detected. The monoisotopic mass values and the manual inspection of the high-resolution MS/MS spectra of the ions at [M+5H]+5 at 689.31, 675.10, 698.11 and 742.76 m/z, and of the ions at [M+4H]+4 at 843.63, 872.39 m/z allowed to establish that the four proteins were alpha defensins 1, 2, 3 and 4.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Saliva

SUBMITTER: Barbara Manconi

LAB HEAD: Barbara Manconi

PROVIDER: PXD012688 | Pride | 2020-01-09

REPOSITORIES: pride

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Dataset's files

Source:

			Action	DRS
	CSM033_Roma_HCD_07102015.raw	Raw
	ManualAnnotation_alpha_defensins_TopDown.xlsx	Xlsx
	SM024_Roma_HCD_250915.raw	Raw
	SM028_Roma_HCD_250915.raw	Raw

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Human Salivary Neutrophil Defensins (Alpha-Defensins)

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