Dataset Information

Vipera ammodytes ammodytes venom proteomics

ABSTRACT: The nose-horned viper, its nominotypical subspecies Vipera ammodytes ammodytes (Vaa) in particular is, medically, the most relevant snake in Europe. The local and systemic clinical manifestations of poisoning by the venom of this snake are the result of the pathophysiological effects inflicted by enzymatic and non-enzymatic venom components acting, most prominently, on blood, cardiovascular and nerve systems. This venom comprises the most complex mixture of pharmacologically active proteins and peptides of all European snakes. To help improve the current antivenom therapy towards higher specificity and efficiency, and to assist drug discovery, we have constructed, by combining transcriptomic and proteomic analyses, the most comprehensive library yet of the Vaa venom proteins and peptides. At the protein level, 57 venom proteins belonging to 16 different protein families have been identified and, with SVSPs, sPLA2s, snaclecs and SVMPs, comprise about 80% of all venom proteins.

INSTRUMENT(S): ion trap

ORGANISM(S): Vipera Ammodytes Ammodytes

TISSUE(S): Venom

SUBMITTER: Adrijana Leonardi

LAB HEAD: Igor Križaj

PROVIDER: PXD012752 | Pride | 2019-05-06

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	2-DEgel.tif	Other
	Vaa_rawdata.zip	Other
	spot_10 (F001674).mzid_spot_10_(F001674).pride.mgf.gz	Mzid
	spot_10 (F001674).pride.mztab.gz	Mztab
	spot_100 (F001644).mzid_spot_100_(F001644).pride.mgf.gz	Mzid

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Publications

Comprehensive Study of the Proteome and Transcriptome of the Venom of the Most Venomous European Viper: Discovery of a New Subclass of Ancestral Snake Venom Metalloproteinase Precursor-Derived Proteins.

Leonardi Adrijana A Sajevic Tamara T Pungerčar Jože J Križaj Igor I

Journal of proteome research 20190424 5

The nose-horned viper, its nominotypical subspecies Vipera ammodytes ammodytes ( Vaa), in particular, is, medically, one of the most relevant snakes in Europe. The local and systemic clinical manifestations of poisoning by the venom of this snake are the result of the pathophysiological effects inflicted by enzymatic and nonenzymatic venom components acting, most prominently, on the blood, cardiovascular, and nerve systems. This venom is a very complex mixture of pharmacologically active protein ...[more]

PMID: 31017792

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