Identification of the early exoproteome of pathogenic Aspergilli, Aspergillus flavus and Aspergillus fumigatus

ABSTRACT: We identified the proteins secreted by A. flavus and A. fumigatus conidia during the early stages of growth. A comparative analysis was done between the exoproteome of the two species to identify the core proteins that were common between the two Aspergilli as well as species specific signature protiens. The common proteins included cell wall polysaccharide modifying enzymes and those required for nutrient acquisition. The core proteome is an indication that A. flavus and A. fumigatus share the common events during germination and growth. On the other hand, each Aspergillus had a unique subset of proteins that could be potential virulence factors or effector molecules. This species-specific exoprotein signature probably reflects the specific requirements of the Aspergillus pathogen to establish an infection in a particular niche.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Aspergillus Fumigatus Af293 Aspergillus Flavus (strain Atcc 200026 / Fgsc A1120 / Nrrl 3357 / Jcm 12722 / Srrc 167)

TISSUE(S): Fungal Spore

DISEASE(S): Keratitis,Aspergillosis

SUBMITTER: Jeya Maheshwari Jayapal  

LAB HEAD: Dharmalingam Kuppamuthu

PROVIDER: PXD012982 | Pride | 2025-01-17

REPOSITORIES: pride