Dataset Information
Protocol for performing and analyzing TPP-TR and TPP-CCR experiments
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): K-562 Cell, Cell Line Cell
SUBMITTER: 
Maria Faelth Savitski
LAB HEAD: Marcus Bantscheff
PROVIDER: PXD013774 | Pride | 2019-05-24
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 0474_F1_R1_P85192B02_TMT10.raw.gz | Raw | |||
| 0474_F1_R1_P85192B03_TMT10.raw.gz | Raw | |||
| 0474_F1_R1_P85192B04_TMT10.raw.gz | Raw | |||
| 0474_F1_R1_P85192B05_TMT10.raw.gz | Raw | |||
| 0474_F1_R1_P85192B06_TMT10.raw.gz | Raw |
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Publications
Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry.
Nature protocols 20150917 10
The direct detection of drug-protein interactions in living cells is a major challenge in drug discovery research. Recently, we introduced an approach termed thermal proteome profiling (TPP), which enables the monitoring of changes in protein thermal stability across the proteome using quantitative mass spectrometry. We determined the intracellular thermal profiles for up to 7,000 proteins, and by comparing profiles derived from cultured mammalian cells in the presence or absence of a drug we sh ...[more]
