Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: Valar Nila Roamio Franklin
LAB HEAD: Clive D'Santos
PROVIDER: PXD013796 | Pride | 2020-05-26
REPOSITORIES: Pride
Items per page: 1 - 5 of 30 |
Clinical cancer research : an official journal of the American Association for Cancer Research 20191107 4
<h4>Purpose</h4>Cyclin-dependent kinase 9 (CDK9) is a transcriptional regulator and potential therapeutic target for many cancers. Multiple nonselective CDK9 inhibitors have progressed clinically but were limited by a narrow therapeutic window. This work describes a novel, potent, and highly selective CDK9 inhibitor, AZD4573.<h4>Experimental design</h4>The antitumor activity of AZD4573 was determined across broad cancer cell line panels <i>in vitro</i> as well as cell line- and patient-derived x ...[more]