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Ancient human brain LC-MS proteomic analysys

ABSTRACT: LC-MS proteomic analysis of a 2,400-year old human brain.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Disease Free

SUBMITTER: Johan Gobom

LAB HEAD: Johan Gobom

PROVIDER: PXD014178 | Pride | 2020-02-04

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	20140908_JG_03_Hels_Cx1_1.mgf	Mgf
	20140908_JG_03_Hels_Cx1_1.raw	Raw
	20140908_JG_04_Hels_Cx1_2.mgf	Mgf
	20140908_JG_04_Hels_Cx1_2.raw	Raw
	20140908_JG_05_Hels_Cx1_3.mgf	Mgf

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Publications

Protein aggregate formation permits millennium-old brain preservation.

Petzold Axel A Lu Ching-Hua CH Groves Mike M Gobom Johan J Zetterberg Henrik H Shaw Gerry G O'Connor Sonia S

Journal of the Royal Society, Interface 20200108 162

Human proteins have not been reported to survive in free nature, at ambient temperature, for long periods. Particularly, the human brain rapidly dissolves after death due to auto-proteolysis and putrefaction. The here presented discovery of 2600-year-old brain proteins from a radiocarbon dated human brain provides new evidence for extraordinary long-term stability of non-amyloid protein aggregates. Immunoelectron microscopy confirmed the preservation of neurocytoarchitecture in the ancient brain ...[more]

PMID: 31910770

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