Proteomics

Dataset Information

0

Salmonella Skp mutant proteomics


ABSTRACT: Global discovery proteomic investigation of Salmonella typhimurium (control strain, Antibiotic resistant, or AcrB mutant) was performed in order to identify cellular processes affected by AcrB.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Bacteria Salmonella Typhimurium (strain 14028s / Sgsc 2262)

SUBMITTER: Alon Savidor  

LAB HEAD: Yechiel Shai

PROVIDER: PXD014818 | Pride | 2020-05-27

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
HFX_8394_YSHA_HLP_KO_1_151118.raw Raw
HFX_8394_YSHA_HLP_KO_2_151118.raw Raw
HFX_8394_YSHA_HLP_MUT_1_151118.raw Raw
HFX_8394_YSHA_HLP_MUT_2_151118.raw Raw
HFX_8394_YSHA_HLP_MUT_3_151118.raw Raw
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Publications

Loss of the Periplasmic Chaperone Skp and Mutations in the Efflux Pump AcrAB-TolC Play a Role in Acquired Resistance to Antimicrobial Peptides in <i>Salmonella typhimurium</i>.

Kapach Gal G   Nuri Reut R   Schmidt Christiane C   Danin Adi A   Ferrera Shir S   Savidor Alon A   Gerlach Roman G RG   Shai Yechiel Y  

Frontiers in microbiology 20200310


Bacterial resistance to antibiotics is a major concern worldwide, leading to an extensive search for alternative drugs. Promising candidates are antimicrobial peptides (AMPs), innate immunity molecules, shown to be highly efficient against multidrug resistant bacteria. Therefore, it is essential to study bacterial resistance mechanisms against them. For that purpose, we used experimental evolution, and isolated a <i>Salmonella enterica</i> serovar <i>typhimurium</i>-resistant line to the AMP 4DK  ...[more]

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