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Transcription profiling of Salmonella enterica serovar Typhimurium to investigate the effects of acrB duisruption

ABSTRACT: Analysis of effect of disruption of acrB on the transcriptome of Salmonella enterica serovar Typhimurium

ORGANISM(S): Salmonella typhimurium

SUBMITTER: Mark Webber 

PROVIDER: E-MEXP-1981 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The global consequence of disruption of the AcrAB-TolC efflux pump in Salmonella enterica includes reduced expression of SPI-1 and other attributes required to infect the host.

Webber Mark A MA   Bailey Andrew M AM   Blair Jessica M A JM   Morgan Eirwen E   Stevens Mark P MP   Hinton Jay C D JC   Ivens Al A   Wain John J   Piddock Laura J V LJ  

Journal of bacteriology 20090501 13

The mechanisms by which RND pumps contribute to pathogenicity are currently not understood. Using the AcrAB-TolC system as a paradigm multidrug-resistant efflux pump and Salmonella enterica serovar Typhimurium as a model pathogen, we have demonstrated that AcrA, AcrB, and TolC are each required for efficient adhesion to and invasion of epithelial cells and macrophages by Salmonella in vitro. In addition, AcrB and TolC are necessary for Salmonella to colonize poultry. Mutants lacking acrA, acrB,  ...[more]

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