Acetylation changes in NQO1 overexpression in Mouse Skeletal Mucscle
Ontology highlight
ABSTRACT:
INSTRUMENT(S): 6550A iFunnel Q-TOF LC/MS
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Skeletal Muscle
SUBMITTER: 
Cole Michel
LAB HEAD: Kristofer Fritz
PROVIDER: PXD015070 | Pride | 2021-09-08
REPOSITORIES: Pride
Dataset's files
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Publications
NQO1 protects obese mice through improvements in glucose and lipid metabolism.
Di Francesco Andrea A Choi Youngshim Y Bernier Michel M Zhang Yingchun Y Diaz-Ruiz Alberto A Aon Miguel A MA Kalafut Krystle K Ehrlich Margaux R MR Murt Kelsey K Ali Ahmed A Pearson Kevin J KJ Levan Sophie S Preston Joshua D JD Martin-Montalvo Alejandro A Martindale Jennifer L JL Abdelmohsen Kotb K Michel Cole R CR Willmes Diana M DM Henke Christine C Navas Placido P Villalba Jose Manuel JM Siegel David D Gorospe Myriam M Fritz Kristofer K Biswal Shyam S Ross David D de Cabo Rafael R de Cabo Rafael R
NPJ aging and mechanisms of disease 20201119 1
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-induced metabolic defects through preservation of glucose homeostasis, insulin sensitivity, and lipid handling with improved physiological outcomes. NQO1-RNA interaction mediated the association with ...[more]
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