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Myelin basic protein phospholipid complexation likely competes with deimination in experimental autoimmune encephalomyelitis mouse model

ABSTRACT: Analysis of deimination of MBP in the precence of different phospholipid classes

INSTRUMENT(S): Q Exactive

ORGANISM(S): Bos Taurus (bovine)

SUBMITTER: Sanjoy Bhattacharya

LAB HEAD: Sanjoy K. Bhattacharya

PROVIDER: PXD015494 | Pride | 2021-09-08

REPOSITORIES: Pride

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			Action	DRS
	LPC14_0.mzML	Mzml
	LPC14_0.mzid.gz	Mzid
	LPC14_0.pride.mgf.gz	Mgf
	LPC14_0.raw	Raw
	LPC16_0.mzML	Mzml

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Publications

Myelin Basic Protein Phospholipid Complexation Likely Competes with Deimination in Experimental Autoimmune Encephalomyelitis Mouse Model.

Valdivia Anddre Osmar AO Agarwal Pratul K PK Bhattacharya Sanjoy K SK

ACS omega 20200616 25

Multiple sclerosis has complex pathogenesis encompassing a variety of components (immunologic, genetic, and environmental). The autoimmunogenicity against the host's myelin basic protein is a major contributor. An increase in myelin basic protein deimination (a post-translational modification) and a change in phospholipid composition have been associated with multiple sclerosis. The interaction of myelin basic protein with phospholipids in the myelin membrane is an important contributor to the s ...[more]

PMID: 32637820

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