Proteomics

Dataset Information

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Wnt activator FOXB2 drives the neuroendocrine differentiation of prostate cancer


ABSTRACT: The Wnt signaling pathway is playing a crucial role during development and adult tissue homeostasis. However, the tissue and cell type-specific regulation of Wnt pathway activity remains incompletely understood. Here we identify FOXB2, an uncharacterized forkhead box family transcription factor, as a potent activator of Wnt signaling in normal and cancer cells. Proximity-dependent biotinylation assay (BioID) coupled with mass spectrometry identified transcriptional co-regulators required for FOXB2-dependent Wnt activation.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

SUBMITTER: Lavanya Moparthi  

LAB HEAD: Dr.Stefan Koch

PROVIDER: PXD015725 | Pride | 2019-10-16

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
181126_BirA_1.RAW.raw Raw
181126_BirA_1.mzid.gz Mzid
181126_FOXB2.RAW.raw Raw
181126_FOXB2.mzid.gz Mzid
181126_b2.mzid_181126_b2.MGF Mzid
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Publications

Wnt activator FOXB2 drives the neuroendocrine differentiation of prostate cancer.

Moparthi Lavanya L   Pizzolato Giulia G   Koch Stefan S  

Proceedings of the National Academy of Sciences of the United States of America 20191014 44


The Wnt signaling pathway is of paramount importance for development and disease. However, the tissue-specific regulation of Wnt pathway activity remains incompletely understood. Here we identify FOXB2, an uncharacterized forkhead box family transcription factor, as a potent activator of Wnt signaling in normal and cancer cells. Mechanistically, FOXB2 induces multiple Wnt ligands, including WNT7B, which increases TCF/LEF-dependent transcription without activating Wnt coreceptor LRP6 or β-catenin  ...[more]

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