Proteomics

Dataset Information

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The oncogenic transcription factor FOXQ1 is a bimodal regulator of Wnt target genes

ABSTRACT: The forkhead box transcription factor FOXQ1 is aberrantly induced in various cancers, and contributes to tumour growth and metastasis. It has been suggested that the oncogenic potential of FOXQ1 may be explained by its activation of the Wnt/β-catenin signalling pathway. However, the mode of action of FOXQ1 in the Wnt pathway remains to be resolved. Here we report that FOXQ1 is bimodal transcriptional regulator of Wnt target gene expression in normal and cancer cells. Using co-immunoprecipitation, proximity proteomics, and reporter assays, we show that FOXQ1 partly engages the Wnt transcriptional complex to promote gene expression via TCF/LEF transcription factors.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

SUBMITTER: Lavanya Moparthi  

LAB HEAD: Stefan Koch

PROVIDER: PXD035624 | Pride | 2022-10-05

REPOSITORIES: Pride

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220321_FOXQ1_1_CHIR.raw Raw
220321_FOXQ1_1_CHIR_0.1da.msf.mzid.gz Mzid
220321_FOXQ1_1_CHIR_0.1da.msf.mzid_220321_FOXQ1_1_CHIR_0.1da.msf.MGF Mzid
220321_FOXQ1_2_CHIR.raw Raw
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The oncogenic transcription factor FOXQ1 is a differential regulator of Wnt target genes.

Pizzolato Giulia G   Moparthi Lavanya L   Söderholm Simon S   Cantù Claudio C   Koch Stefan S  

Journal of cell science 20221010 19

The forkhead box transcription factor FOXQ1 contributes to the pathogenesis of carcinomas. In colorectal cancers, FOXQ1 promotes tumour metastasis by inducing epithelial-to-mesenchymal transition (EMT) of cancer cells. FOXQ1 may exacerbate cancer by activating the oncogenic Wnt/β-catenin signalling pathway. However, the role of FOXQ1 in the Wnt pathway remains to be resolved. Here, we report that FOXQ1 is an activator of Wnt-induced transcription and regulator of β-catenin target gene expression  ...[more]

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