Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
SUBMITTER: Lavanya Moparthi
LAB HEAD: Stefan Koch
PROVIDER: PXD030464 | Pride | 2022-10-05
REPOSITORIES: Pride
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201218_Q1_1.raw | Raw | |||
201218_Q1_1_New.mzid.gz | Mzid | |||
201218_Q1_1_New.mzid_201218_Q1_1_New.MGF | Mzid | |||
201218_Q1_2.raw | Raw | |||
201218_Q1_2_New.mzid.gz | Mzid |
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Journal of cell science 20221010 19
The forkhead box transcription factor FOXQ1 contributes to the pathogenesis of carcinomas. In colorectal cancers, FOXQ1 promotes tumour metastasis by inducing epithelial-to-mesenchymal transition (EMT) of cancer cells. FOXQ1 may exacerbate cancer by activating the oncogenic Wnt/β-catenin signalling pathway. However, the role of FOXQ1 in the Wnt pathway remains to be resolved. Here, we report that FOXQ1 is an activator of Wnt-induced transcription and regulator of β-catenin target gene expression ...[more]