Proteomics

Dataset Information

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The oncogene FOXQ1 is a selective activator of Wnt/β-catenin signalling


ABSTRACT: The forkhead box transcription factor FOXQ1 is aberrantly induced in various cancers, and contributes to tumour growth and metastasis. It has been suggested that the oncogenic potential of FOXQ1 may be explained by its activation of the Wnt/β-catenin signalling pathway.However, the mode of action of FOXQ1 in the Wnt pathway remains to be resolved. Here we report that FOXQ1 is bimodal transcriptional activator of Wnt target gene expression in normal and cancer cells. Using co-immunoprecipitation, proximity proteomics, and reporter assays, we show that FOXQ1 engages the Wnt transcriptional complex to promote gene expressionvia TCF/LEF transcription factors.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

SUBMITTER: Lavanya Moparthi  

LAB HEAD: Stefan Koch

PROVIDER: PXD030464 | Pride | 2022-10-05

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
201218_Q1_1.raw Raw
201218_Q1_1_New.mzid.gz Mzid
201218_Q1_1_New.mzid_201218_Q1_1_New.MGF Mzid
201218_Q1_2.raw Raw
201218_Q1_2_New.mzid.gz Mzid
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Publications

The oncogenic transcription factor FOXQ1 is a differential regulator of Wnt target genes.

Pizzolato Giulia G   Moparthi Lavanya L   Söderholm Simon S   Cantù Claudio C   Koch Stefan S  

Journal of cell science 20221010 19


The forkhead box transcription factor FOXQ1 contributes to the pathogenesis of carcinomas. In colorectal cancers, FOXQ1 promotes tumour metastasis by inducing epithelial-to-mesenchymal transition (EMT) of cancer cells. FOXQ1 may exacerbate cancer by activating the oncogenic Wnt/β-catenin signalling pathway. However, the role of FOXQ1 in the Wnt pathway remains to be resolved. Here, we report that FOXQ1 is an activator of Wnt-induced transcription and regulator of β-catenin target gene expression  ...[more]

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