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CD4+ Th immunogenicity of Ascaris spp.

ABSTRACT: Application of a reconstituted in vitro system to define the CD4+ Th immunogenicity of complex antigenic mixtures.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Ascaris Suum

TISSUE(S): Secretion

SUBMITTER: Miguel Alvaro

LAB HEAD: Christian Freund

PROVIDER: PXD015924 | Pride | 2020-03-04

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	18_03_19_ascaris_male_female_18O_new_conds_MA_peps.txt	Txt
	18_03_19_ascaris_male_female_18O_new_conds_MA_proteins.txt	Txt
	18_03_19_ascaris_male_female_18O_new_conds_MB_peps.txt	Txt
	18_03_19_ascaris_male_female_18O_new_conds_MB_proteins.txt	Txt
	MA2_01.raw	Raw

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Publications

CD4+ Th immunogenicity of the Ascaris spp. secreted products.

Ebner Friederike F Morrison Eliot E Bertazzon Miriam M Midha Ankur A Hartmann Susanne S Freund Christian C Álvaro-Benito Miguel M

NPJ vaccines 20200320

Ascaris spp. is a major health problem of humans and animals alike, and understanding the immunogenicity of its antigens is required for developing urgently needed vaccines. The parasite-secreted products represent the most relevant, yet complex (>250 proteins) antigens of Ascaris spp. as defining the pathogen-host interplay. We applied an in vitro antigen processing system coupled to quantitative proteomics to identify potential CD4+ Th cell epitopes in As ...[more]

PMID: 32218997

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CD4+ Th immunogenicity of Ascaris spp.

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