Proteomics

Dataset Information

0

Human macrophages LC-MS/MS in the proteome and secretome


ABSTRACT: Proteome and secretome quantitative LC-MS/MS (iTRAQ) of human THP-1 derived macrophages.

INSTRUMENT(S): Velos Plus

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Macrophage

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Maciej Suski  

LAB HEAD: Rafał Olszanecki

PROVIDER: PXD017787 | Pride | 2020-10-15

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
iTRAQ1_R1_S1.raw Raw
iTRAQ1_R1_S1.tandem.pep.xml Pepxml
iTRAQ1_R1_S1_comet.pep.xml Pepxml
iTRAQ1_R1_S2.raw Raw
iTRAQ1_R1_S2.tandem.pep.xml Pepxml
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Publications

Decrease of the pro-inflammatory M1-like response by inhibition of dipeptidyl peptidases 8/9 in THP-1 macrophages - quantitative proteomics of the proteome and secretome.

Suski Maciej M   Wiśniewska Anna A   Kuś Katarzyna K   Kiepura Anna A   Stachowicz Aneta A   Stachyra Kamila K   Czepiel Klaudia K   Madej Józef J   Olszanecki Rafał R  

Molecular immunology 20200929


<h4>Background</h4>Cellular peptidases are an emerging target of novel pharmacological strategies in inflammatory diseases and cancer. In this context, the dipeptidyl peptidases 8 and 9 (DPP8/9) have gained special attention due to their activities in the immune cells. However, in spite of more than hundred protein substrates identified to date by mass spectrometry-based analysis, the cellular DPP8/9 functions are still elusive.<h4>Methods</h4>We applied the proteomic approach (iTRAQ-2DLC-MS/MS)  ...[more]

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