Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Uwe PLessmann
LAB HEAD: Henning Urlaub
PROVIDER: PXD018049 | Pride | 2021-04-13
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 255 |
Barysch Sina V SV Stankovic-Valentin Nicolas N Miedema Tim T Karaca Samir S Doppel Judith J Nait Achour Thiziri T Vasudeva Aarushi A Wolf Lucie L Sticht Carsten C Urlaub Henning H Melchior Frauke F
EMBO reports 20210122 3
Molecular switches are essential modules in signaling networks and transcriptional reprogramming. Here, we describe a role for small ubiquitin-related modifier SUMO as a molecular switch in epidermal growth factor receptor (EGFR) signaling. Using quantitative mass spectrometry, we compare the endogenous SUMO proteomes of HeLa cells before and after EGF stimulation. Thereby, we identify a small group of transcriptional coregulators including IRF2BP1, IRF2BP2, and IRF2BPL as novel players in EGFR ...[more]