Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): T Cell, Leukocyte, Bone Marrow, Blood
DISEASE(S): Acute Leukemia,Chronic Myeloid Leukemia
SUBMITTER: Grégory La Sala
LAB HEAD: Oliver Hantschel
PROVIDER: PXD018374 | Pride | 2020-07-10
REPOSITORIES: Pride
Items per page: 1 - 5 of 81 |
Nature communications 20200817 1
The transcription factor STAT3 is frequently activated in human solid and hematological malignancies and remains a challenging therapeutic target with no approved drugs to date. Here, we develop synthetic antibody mimetics, termed monobodies, to interfere with STAT3 signaling. These monobodies are highly selective for STAT3 and bind with nanomolar affinity to the N-terminal and coiled-coil domains. Interactome analysis detects no significant binding to other STATs or additional off-target protei ...[more]