Dataset Information
Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell
DISEASE(S): Disease Free
SUBMITTER: 
Behnam Nabet
LAB HEAD: Nathanael Gray
PROVIDER: PXD018937 | Pride | 2020-09-21
REPOSITORIES: pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| EWS-FLI-FKBP12_dTAG_f1.mzIdentML | Mzid | |||
| EWS-FLI-FKBP12_dTAG_f1.raw | Raw | |||
| EWS-FLI-FKBP12_dTAG_f10.mzIdentML | Mzid | |||
| EWS-FLI-FKBP12_dTAG_f10.raw | Raw | |||
| EWS-FLI-FKBP12_dTAG_f11.mzIdentML | Mzid |
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Publications
Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules.
Nature communications 20200918 1
Chemical biology strategies for directly perturbing protein homeostasis including the degradation tag (dTAG) system provide temporal advantages over genetic approaches and improved selectivity over small molecule inhibitors. We describe dTAG<sup>V</sup>-1, an exclusively selective VHL-recruiting dTAG molecule, to rapidly degrade FKBP12<sup>F36V</sup>-tagged proteins. dTAG<sup>V</sup>-1 overcomes a limitation of previously reported CRBN-recruiting dTAG molecules to degrade recalcitrant oncogenes, ...[more]
