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Identification of ribosome proteins bound to IRES in hypoxia

ABSTRACT: Hypoxic conditions prompt internal ribosome entry site (IRES)-mediated translation of some of the hallmark cancer genes, such as VEGF. This translational switch is extremely vital for cell survival and tumor progression. Heterogeneity in ribosomes due to the diversity of ribosomal RNA (rRNA) and protein composition has been postulated to generate ‘specialized ribosomes’ that differentially regulate translation. A VEGF IRES sequence was used as bait to identify unique proteins bound at the IRES in breast cancer cells grown in hypoxia.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Breast Cancer

SUBMITTER: Brandon Metge

LAB HEAD: Rajeev Samant

PROVIDER: PXD019238 | Pride | 2021-01-06

REPOSITORIES: Pride

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			Action	DRS
	Mudpit_jm_20180614_RSumant_10AC_1.mzid.gz	Mzid
	Mudpit_jm_20180614_RSumant_10AC_1.mzid_Mudpit_jm_20180614_RSumant_10AC_1.MGF	Mzid
	Mudpit_jm_20180614_RSumant_10AC_1.mzid_Mudpit_jm_20180614_RSumant_10AC_1.pride.mgf.gz	Mzid
	Mudpit_jm_20180614_RSumant_10AC_1.pride.mztab.gz	Mztab
	Mudpit_jm_20180614_RSumant_10A_1.mzid.gz	Mzid

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Identification of ribosome proteins bound to IRES in hypoxia

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