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ECM of proliferative vs dormant HNSCC

ABSTRACT: The goal of this project is to characterize the ECM composition of actively proliferative and dormant head and neck squamous cell carcinoma xenografts and identify components of the ECM niche instructing tumor cell dormancy.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

DISEASE(S): Neck Carcinoma

SUBMITTER: George Chlipala

LAB HEAD: Alexandra Naba

PROVIDER: PXD018883 | Pride | 2021-08-26

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	Naba-1-10x_180123194318.mgf	Mgf
	Naba-1-10x_180123194318.mzid.gz	Mzid
	Naba-1-10x_180123194318.pride.mgf.gz	Mgf
	Naba-1-10x_180123194318.pride.mztab.gz	Mztab
	Naba-1-10x_180123194318.raw	Raw

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Publications

A tumor-derived type III collagen-rich ECM niche regulates tumor cell dormancy.

Di Martino Julie S JS Nobre Ana Rita AR Mondal Chandrani C Taha Isra I Farias Eduardo F EF Fertig Elana J EJ Naba Alexandra A Aguirre-Ghiso Julio A JA Bravo-Cordero Jose Javier JJ

Nature cancer 20211213 1

Cancer cells disseminate and seed in distant organs, where they can remain dormant for many years before forming clinically detectable metastases. Here we studied how disseminated tumor cells sense and remodel the extracellular matrix (ECM) to sustain dormancy. ECM proteomics revealed that dormant cancer cells assemble a type III collagen-enriched ECM niche. Tumor-derived type III collagen is required to sustain tumor dormancy, as its disruption restores tumor cell proliferation through DDR1-med ...[more]

PMID: 35121989

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ECM of proliferative vs dormant HNSCC

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