Dataset Information

Cerebrospinal Fluid (CSF) Proteomics of A30P-αS mice

ABSTRACT: Here, we took advantage of well-defined mouse models for α-synucleinopathy (A30P-αS ) to explore proteome changes in the cerebrospinal fluid which are related to these distinct proteopathic lesions. Non-targeted liquid chromatography-mass spectrometry revealed that the majority of proteins that undergo age- and disease-related changes in either mouse model was linked to microglia, and more specifically to previously described disease state-specific microglia transcriptomic signatures. The finding that such transcriptomic changes translate into corresponding protein changes in cerebrospinal fluid is of high clinical relevance, supporting efforts to identify bodily fluid biomarkers that reflect the various functional states of microglial activation in Parkinson’s disease.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cerebrospinal Fluid

DISEASE(S): Parkinson's Disease

SUBMITTER: Stephan Mueller

LAB HEAD: Stefan F. Lichtenthaler

PROVIDER: PXD021356 | Pride | 2022-06-21

REPOSITORIES: pride

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Signatures of glial activity can be detected in the CSF proteome.

Eninger Timo T Müller Stephan A SA Bacioglu Mehtap M Schweighauser Manuel M Lambert Marius M Maia Luis F LF Neher Jonas J JJ Hornfeck Sarah M SM Obermüller Ulrike U Kleinberger Gernot G Haass Christian C Kahle Philipp J PJ Staufenbiel Matthias M Ping Lingyan L Duong Duc M DM Levey Allan I AI Seyfried Nicholas T NT Lichtenthaler Stefan F SF Jucker Mathias M Kaeser Stephan A SA

Proceedings of the National Academy of Sciences of the United States of America 20220606 24

Single-cell transcriptomics has revealed specific glial activation states associated with the pathogenesis of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease. While these findings may eventually lead to new therapeutic opportunities, little is known about how these glial responses are reflected by biomarker changes in bodily fluids. Such knowledge, however, appears crucial for patient stratification, as well as monitoring disease progression and treatment responses in cli ...[more]

PMID: 35666874

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Dataset Information

Cerebrospinal Fluid (CSF) Proteomics of A30P-αS mice

Dataset's files

Publications

Signatures of glial activity can be detected in the CSF proteome.

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