Proteomics

Dataset Information

0

Col4a3 mouse glomerular datasets


ABSTRACT: Glomeruli were isolated from Col4a3-/- and Ctrl mice. The extracellular matrix was enriched and both cellular and matrix fraction were analysed by mass spectrometry.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Kidney

SUBMITTER: Franziska Lausecker  

LAB HEAD: Rachel Lennon

PROVIDER: PXD022392 | Pride | 2022-08-12

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20150313_MR_01.raw Raw
20150313_MR_02.raw Raw
20150313_MR_03.raw Raw
20150313_MR_04.raw Raw
20150313_MR_05.raw Raw
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Publications


<h4>Background</h4>Accumulation of extracellular matrix in organs and tissues is a feature of both aging and disease. In the kidney, glomerulosclerosis and tubulointerstitial fibrosis accompany the decline in function, which current therapies cannot address, leading to organ failure. Although histologic and ultrastructural patterns of excess matrix form the basis of human disease classifications, a comprehensive molecular resolution of abnormal matrix is lacking.<h4>Methods</h4>Using mass spectr  ...[more]

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