Proteomics

Dataset Information

0

Col4a5 mouse glomerular extracellular matrix


ABSTRACT: Alport mouse model (Col4a5) have been submitted for proteomic analysis. Glomeruli have been isolated from mouse kidneys, extracellular matrix has been enriched and analysed by mass spectrometry.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Kidney

SUBMITTER: Franziska Lausecker  

LAB HEAD: Rachel Lennon

PROVIDER: PXD022227 | Pride | 2022-08-12

REPOSITORIES: pride

Dataset's files

Source:
Action DRS
20170109_6pm04.raw Raw
20170109_6pm06.raw Raw
20170109_6pm07.raw Raw
20170109_6pm08.raw Raw
20170109_MR01.raw Raw
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Publications


<h4>Background</h4>Accumulation of extracellular matrix in organs and tissues is a feature of both aging and disease. In the kidney, glomerulosclerosis and tubulointerstitial fibrosis accompany the decline in function, which current therapies cannot address, leading to organ failure. Although histologic and ultrastructural patterns of excess matrix form the basis of human disease classifications, a comprehensive molecular resolution of abnormal matrix is lacking.<h4>Methods</h4>Using mass spectr  ...[more]

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