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Systemic inflammation and metabolic disturbances are central pathways related to mortality of ill severely malnourished children

ABSTRACT: This study aimed to characterize systemic processes associated with inpatient mortality among children with CSM using multi-omics approaches

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: James Njunge

LAB HEAD: James Njunge

PROVIDER: PXD022792 | Pride | 2022-05-23

REPOSITORIES: Pride

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			Action	DRS
	F75_BATCH1.mgf	Mgf
	F75_BATCH1.raw	Raw
	F75_BATCH10.mgf	Mgf
	F75_BATCH10.raw	Raw
	F75_BATCH11.mgf	Mgf

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Publications

Systemic inflammation and metabolic disturbances underlie inpatient mortality among ill children with severe malnutrition.

Wen Bijun B Njunge James M JM Bourdon Celine C Gonzales Gerard Bryan GB Gichuki Bonface M BM Lee Dorothy D Wishart David S DS Ngari Moses M Chimwezi Emmanuel E Thitiri Johnstone J Mwalekwa Laura L Voskuijl Wieger W Berkley James A JA Bandsma Robert Hj RH

Science advances 20220216 7

Children admitted to hospital with an acute illness and concurrent severe malnutrition [complicated severe malnutrition (CSM)] have a high risk of dying. The biological processes underlying their mortality are poorly understood. In this case-control study nested within a multicenter randomized controlled trial among children with CSM in Kenya and Malawi, we found that blood metabolomic and proteomic profiles robustly differentiated children who died (<i>n</i> = 92) from those who survived (<i>n< ...[more]

PMID: 35171682

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