Dataset Information

ChIRP-MS of the lncRNA SAMMSON in uveal melanoma

ABSTRACT: Long non-coding RNAs (lncRNAs) can exhibit cell-type or even cancer-type specific expression profiles, making them highly attractive as therapeutic targets. PAN cancer RNA sequencing data revealed sustained expression of the SAMMSON lncRNA in uveal melanoma (UM), the most common primary intraocular malignancy in adults. Currently, there are no effective treatments for UM patients with metastatic disease, resulting in a median survival time of 6-12 months. We aimed to investigate the therapeutic potential of SAMMSON inhibition in UM.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Louis Delhaye

LAB HEAD: Sven Eyckerman

PROVIDER: PXD023511 | Pride | 2021-10-04

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	B003221_Ap_CMB-189_SVEYC_Louis_APMS_OMM1-SAMSON_rep1.raw	Raw
	B003223_Ap_CMB-189_SVEYC_Louis_APMS_OMM1-LacZ_rep1.raw	Raw
	B003225_Ap_CMB-189_SVEYC_Louis_APMS_OMM1-SAMSON_rep2.raw	Raw
	B003227_Ap_CMB-189_SVEYC_Louis_APMS_OMM1-LacZ_rep2.raw	Raw
	B003229_Ap_CMB-189_SVEYC_Louis_APMS_OMM1-SAMSON_rep3.raw	Raw

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Publications

The long non-coding RNA SAMMSON is essential for uveal melanoma cell survival.

Dewaele Shanna S Delhaye Louis L De Paepe Boel B de Bony Eric James EJ De Wilde Jilke J Vanderheyden Katrien K Anckaert Jasper J Yigit Nurten N Nuytens Justine J Vanden Eynde Eveline E Smet Joél J Verschoore Maxime M Nemati Fariba F Decaudin Didier D Rodrigues Manuel M Zhao Peihua P Jochemsen Aart A Leucci Eleonora E Vandesompele Jo J Van Dorpe Jo J Marine Jean-Christophe JC Van Coster Rudy R Eyckerman Sven S Mestdagh Pieter P

Oncogene 20210910 1

Long non-coding RNAs (lncRNAs) can exhibit cell-type and cancer-type specific expression profiles, making them highly attractive as therapeutic targets. Pan-cancer RNA sequencing data revealed broad expression of the SAMMSON lncRNA in uveal melanoma (UM), the most common primary intraocular malignancy in adults. Currently, there are no effective treatments for UM patients with metastatic disease, resulting in a median survival time of 6-12 months. We aimed to investigate the therapeutic potentia ...[more]

PMID: 34508176

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