Proteomics

Dataset Information

0

Proteomics of Zinc-limited Mycobacterium tuberculosis


ABSTRACT: Mycobacterium tuberculosis H37Rv (Mtb) grown in chemically defined medium replete for Zinc and limited for Zinc

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mycobacterium Tuberculosis H37rv

SUBMITTER: Endrei Marcantonio  

LAB HEAD: Sladjana Prisic

PROVIDER: PXD024389 | Pride | 2021-04-23

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
Mtb_-Zn_Rep1.raw Raw
Mtb_-Zn_Rep2.raw Raw
Mtb_-Zn_Rep3.raw Raw
Mtb__Zn_-Zn_X__Tandem_searches.xlsx Xlsx
Mtb__Zn_Rep1.raw Raw
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Publications


Mycobacterium tuberculosis (Mtb) has complex and dynamic interactions with the human host, and subpopulations of Mtb that emerge during infection can influence disease outcomes. This study implicates zinc ion (Zn2+) availability as a likely driver of bacterial phenotypic heterogeneity in vivo. Zn2+ sequestration is part of "nutritional immunity", where the immune system limits micronutrients to control pathogen growth, but this defense mechanism seems to be ineffective in controlling Mtb infecti  ...[more]

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