Dataset Information
Proteomics of Zinc-limited Mycobacterium tuberculosis
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mycobacterium Tuberculosis H37rv
SUBMITTER: 
Endrei Marcantonio
LAB HEAD: Sladjana Prisic
PROVIDER: PXD024389 | Pride | 2021-04-23
REPOSITORIES: pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| Mtb_-Zn_Rep1.raw | Raw | |||
| Mtb_-Zn_Rep2.raw | Raw | |||
| Mtb_-Zn_Rep3.raw | Raw | |||
| Mtb__Zn_-Zn_X__Tandem_searches.xlsx | Xlsx | |||
| Mtb__Zn_Rep1.raw | Raw |
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Publications
Zinc limitation triggers anticipatory adaptations in Mycobacterium tuberculosis.
PLoS pathogens 20210514 5
Mycobacterium tuberculosis (Mtb) has complex and dynamic interactions with the human host, and subpopulations of Mtb that emerge during infection can influence disease outcomes. This study implicates zinc ion (Zn2+) availability as a likely driver of bacterial phenotypic heterogeneity in vivo. Zn2+ sequestration is part of "nutritional immunity", where the immune system limits micronutrients to control pathogen growth, but this defense mechanism seems to be ineffective in controlling Mtb infecti ...[more]
