Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Hepatocyte, Cell Culture
SUBMITTER: Ranen Aviner
LAB HEAD: Raul Andino
PROVIDER: PXD024546 | Pride | 2021-08-17
REPOSITORIES: Pride
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B20171030-06_Huh7_PV2h_1.raw | Raw | |||
B20171030-07_Huh7_PV2h_2.raw | Raw |
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Nature 20210818 7873
Viral pathogens are an ongoing threat to public health worldwide. Analysing their dependence on host biosynthetic pathways could lead to effective antiviral therapies<sup>1</sup>. Here we integrate proteomic analyses of polysomes with functional genomics and pharmacological interventions to define how enteroviruses and flaviviruses remodel host polysomes to synthesize viral proteins and disable host protein production. We find that infection with polio, dengue or Zika virus markedly modifies pol ...[more]