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Quantitative proteomics of Hsp90 inhibition in Leishmania mexicana

ABSTRACT: Using a combination of mass spectrometry-based quantitative proteomics, chemical and metabolic labelling, we provide the first protein-level evidence that the Hsp90 inhibition affects the expression of hundreds of proteins in Leishmania spp. Our study defines the Leishmania parasite’s response to Hsp90 inhibition at its global proteome and provides a rich resource for future studies on Leishmania biology and antileishmanial drug development.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Leishmania Mexicana

SUBMITTER: Kalesh Karunakaran

LAB HEAD: Karunakaran Kalesh

PROVIDER: PXD024764 | Pride | 2021-04-23

REPOSITORIES: Pride

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			Action	DRS
	DMSO_D1.wiff	Wiff
	DMSO_D2.wiff	Wiff
	DMSO_D3.wiff	Wiff
	Tanespi_T1.wiff	Wiff
	Tanespi_T2.wiff	Wiff

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