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Magnetic ConA nanoparticles enriched proteins from urine samples of healthy donors and lung cancer patients

ABSTRACT: In this project, we used magnetic ConA nanoparticles to purify glycosylated proteins from urine samples of healthy donors and lung cancer patients to discover potential urinary protein biomarker for lung cancer.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Urine

DISEASE(S): Lung Cancer

SUBMITTER: Honglv Jiang

LAB HEAD: Guoqiang Xu

PROVIDER: PXD025856 | Pride | 2021-10-12

REPOSITORIES: Pride

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			Action	DRS
	Ctrl-Urine-ConA-1.raw	Raw
	Ctrl-Urine-ConA-2.raw	Raw
	Ctrl-Urine-ConA-3.raw	Raw
	Ctrl-Urine-ConA-4.raw	Raw
	Ctrl-Urine-ConA-5.raw	Raw

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Publications

Quantitative proteomic analysis of glycosylated proteins enriched from urine samples with magnetic ConA nanoparticles identifies potential biomarkers for small cell lung cancer.

Zhang Zhiyu Z Cheng Xinyu X Jiang Honglv H Gu Jingyu J Yin Yunfei Y Shen Zhijia Z Xu Changgang C Pu Zhongjian Z Li Jia-Bin JB Xu Guoqiang G

Journal of pharmaceutical and biomedical analysis 20210831

Lung cancer has high morbidity and mortality and small cell lung cancer (SCLC) is a highly invasive malignant tumor with a very unfavorable survival rate. Early diagnosis and treatment can result in better prognosis for the SCLC patients but current diagnostic methods are either invasive or incapable for large-scale screen. Therefore, discovering biomarkers for early diagnosis of SCLC is of importance. In this work, we covalently coupled Concanavalin A (ConA) to functionalized magnetic nanoparti ...[more]

PMID: 34509662

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