Proteomics

Dataset Information

0

The attenuating effect of low-intensity pulsed ultrasound on hypoxia-induced chondrocyte damage in TMJ osteoarthritis based on TMT labeling quantitative proteomic analysis

ABSTRACT: Temporomandibular joint osteoarthritis (TMJOA) is a common group of clinical diseases and is an important subtype of temporomandibular joint disorder (TMD). Increased intrajoint pressure or weakened penetration can exacerbate the hypoxic state of the condylar cartilage microenvironment. In this study, TMT labeling quantitative proteomic technology was used to comprehensively explore the impacts of and pathways affected by LIPUS on the biological functions of chondrocytes under hypoxic conditions. Bioinformatic analysis revealed differentially expressed proteins (DEPs) in the N group versus the L group and the L group versus the LP group. Considering the results of gene ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, and protein-protein interaction (PPI) network analyses, we hypothesized that LIPUS can activate the FAK signaling pathway. This study identified a new molecular marker to determine the efficacy of LIPUS in TMJOA, providing a theoretical basis for the clinical application of LIPUS in the treatment of TMJOA.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Cell Culture

SUBMITTER: Wei Geng  

LAB HEAD: Wei Geng

PROVIDER: PXD026677 | Pride | 2022-02-17

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
HA010TQ_01.raw Raw
HA010TQ_02.raw Raw
HA010TQ_03.raw Raw
HA010TQ_04.raw Raw
HA010TQ_05.raw Raw
Items per page:
1 - 5 of 15
altmetric image

Publications

The Attenuating Effect of Low-Intensity Pulsed Ultrasound on Hypoxia-Induced Rat Chondrocyte Damage in TMJ Osteoarthritis Based on TMT Labeling Quantitative Proteomic Analysis.

Du Sa S   Liang Chao C   Sun Yujie Y   Ma Bowen B   Gao Wenmo W   Geng Wei W  

Frontiers in pharmacology 20211214

Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease with a complex and multifactorial etiology. An increased intrajoint pressure or weakened penetration can exacerbate the hypoxic state of the condylar cartilage microenvironment. Our group previously simulated the hypoxic environment of TMJOA <i>in vitro</i>. Low-intensity pulsed ultrasound (LIPUS) stimulation attenuates chondrocyte matrix degradation <i>via</i> a hypoxia-inducible factor (HIF) pathway-associated mechanism,  ...[more]

Similar Datasets

Proteomics Leptin-deficient Mouse Serum TMT-label Discovery Proteomics Profiling
2022-10-14 | PXD027937 | Pride
Proteomics Leptin-deficient Mouse Liver TMT-label Discovery Proteomics Profiling
2022-10-14 | PXD027938 | Pride
Proteomics Proteomics and phosphoproteomics analysis of the vitreous in idiopathic epiretinal membrane patients
2023-12-04 | PXD030278 | Pride
Proteomics Acetylation profiles in the metabolic process of glioma-associated seizures
2022-02-17 | PXD027864 | Pride
Proteomics TMT-Based Quantitative Proteomic Analysis Reveals the Crucial Biological Pathways Involved in Brain Injury Induced by Chest Exposure to Shock Waves
2021-12-30 | PXD025204 | Pride
Proteomics iTRAQ-based quantitative serum proteomic analysis in ischemic stroke patients
2021-10-12 | PXD026950 | Pride
Proteomics The proteomics data of human umbilical vein endothelial cells under lethal ischemia condition
2023-03-11 | PXD031313 | Pride
Proteomics Proteome-Wide Analyses Reveal Diverse Functions of Acylation Proteins in Neurospora crassa
2021-01-26 | PXD022001 | Pride
Transcriptomics Low oxygen responsive small RNAs in Arabidopsis
2009-09-30 | E-GEOD-16971 | biostudies-arrayexpress
Proteomics Systematic analysis of the lysine malonylome in Sanghuangporus sanghuang
2022-02-17 | PXD025835 | Pride