Proteomics

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Viral fallout: Semen proteome reveals COVID-19 dysregulates several biological processes linked to male reproductive function

ABSTRACT: The current global outbreak of COVID-19 has significantly impacted several organ systems. Male reproductive organs are among the potential targets of SARS-CoV-2 infection owing to the presence of abundant viral receptors; ACE2 and TMPRSS2 in the testis. However, the questions pertaining to the long term effects of SARS-CoV-2 infection on male fertility are still unanswered. For this study, we procured the semen samples of COVID-19 recovered patients and performed mass spectrometry based proteomic studies to understand the impact of the disease on the biological processes involved in reproductive health.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Semen, Sperm

DISEASE(S): Covid-19

SUBMITTER: Avinash singh  

LAB HEAD: Sanjeeva Srivastava

PROVIDER: PXD026703 | Pride | 2022-04-04

REPOSITORIES: Pride

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03112020_Fusion_SCT006a.raw Raw
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Publications

Semen Proteomics of COVID-19 Convalescent Men Reveals Disruption of Key Biological Pathways Relevant to Male Reproductive Function.

Ghosh Susmita S   Parikh Swapneil S   Nissa Mehar Un MU   Acharjee Arup A   Singh Avinash A   Patwa Dhruv D   Makwana Prashant P   Athalye Arundhati A   Barpanda Abhilash A   Laloraya Malini M   Srivastava Sanjeeva S   Parikh Firuza F  

ACS omega 20220307 10

A considerable section of males suffered from COVID-19, with many experiencing long-term repercussions. Recovered males have been documented to have compromised fertility, albeit the mechanisms remain unclear. We investigated the impact of COVID-19 on semen proteome following complete clinical recovery using mass spectrometry. A label-free quantitative proteomics study involved 10 healthy fertile subjects and 17 COVID-19-recovered men. With 1% false discovery rate and >1 unique peptide stringenc  ...[more]

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