Proteomics

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Renal cell-derived extracellular vesicles as a modulator of tubuloid functional maturation

ABSTRACT: Tubuloids are adult stem cell-based kidney organoids with promising application in kidney disease modelling and drug screening. However, tubuloids still present limited transepithelial transport capacity, which is essential for the kidney’s function. The extracellular vesicles (EVs) are cell-derived vesicular structures known to regulate several cellular processes, including development and maturation. This study explores the potential of EVs derived from renal cells to support tubuloid functional maturation by increasing the levels of organic anion transport 1 (OAT1), a protein involved in renal waste handling.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Epithelial Cell Of Proximal Tubule

DISEASE(S): Kidney Disease

SUBMITTER: Franziska Voellmy  

LAB HEAD: Rosalinde Masereeuw

PROVIDER: PXD027142 | Pride | 2022-08-12

REPOSITORIES: Pride

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The prevalence of end-stage kidney disease (ESKD) is rapidly increasing with the need for regenerative therapies. Adult stem cell derived kidney tubuloids have the potential to functionally mimic the adult kidney tubule, but still lack the expression of important transport proteins needed for waste removal. Here, we investigated the potential of extracellular vesicles (EVs) obtained from matured kidney tubular epithelial cells to modulate in vitro tubuloids functional maturation. We focused on o  ...[more]

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