Ontology highlight
ABSTRACT:
INSTRUMENT(S): Synapt MS, Orbitrap Fusion
ORGANISM(S): Rattus Norvegicus (rat) Bos Taurus (bovine)
TISSUE(S): Testis
SUBMITTER: Julien Marcoux
LAB HEAD: Julien Marcoux
PROVIDER: PXD027436 | Pride | 2022-04-07
REPOSITORIES: Pride
Items per page: 1 - 5 of 163 |
Proceedings of the National Academy of Sciences of the United States of America 20220404 15
During spermatogenesis, spermatogonia undergo a series of mitotic and meiotic divisions on their path to spermatozoa. To achieve this, a succession of processes requiring high proteolytic activity are in part orchestrated by the proteasome. The spermatoproteasome (s20S) is specific to the developing gametes, in which the gamete-specific α4s subunit replaces the α4 isoform found in the constitutive proteasome (c20S). Although the s20S is conserved across species and was shown to be crucial for ge ...[more]