Dataset Information

Quantitative proteomic analysis of bronchoalveolar lavage fluid in West Highland white terriers with canine idiopathic pulmonary fibrosis C4PR_LIV

ABSTRACT: Canine idiopathic pulmonary fibrosis (CIPF) is a chronic, progressive, interstitial fibrosing lung disease, manifesting as cough, exercise intolerance and ultimately, dyspnea and respiratory failure. It mainly affects West Highland white terriers (WHWTs), lacks curable treatment and has a poor prognosis. Aspiration of gastroesophageal refluxate may play a role in the development of CIPF. In the first part of this study, we completed label-free quantitative proteomic analysis of bronchoalveolar lavage fluid (BALF) from CIPF and healthy WHWTs. In the second part, we evaluated potential protein markers of reflux aspiration from canine gastric juice and vomitus and evaluated whether these were present in BALF from the two groups.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Canis Familiaris (dog) (canis Lupus Familiaris)

TISSUE(S): Bronchoalveolar Lavage, Gastric Juice

DISEASE(S): Idiopathic Pulmonary Fibrosis

SUBMITTER: Rosemary Maher

LAB HEAD: Robert John Beynon

PROVIDER: PXD028916 | Pride | 2022-05-20

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	REM_06062018_290_1uL.mgf	Mgf
	REM_06062018_290_1uL.mzid.gz	Mzid
	REM_06062018_290_1uL.raw	Raw
	REM_06062018_313109_1uL.mgf	Mgf
	REM_06062018_313109_1uL.mzid.gz	Mzid

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Quantitative proteomic analysis of bronchoalveolar lavage fluid in West Highland white terriers with canine idiopathic pulmonary fibrosis.

Maher Rosemary E RE Määttä Merita M Beynon Robert J RJ Laurila Henna P HP McNamara Paul S PS Rajamäki Minna M MM

BMC veterinary research 20220330 1

<h4>Background</h4>Canine idiopathic pulmonary fibrosis (CIPF) is a chronic, progressive, interstitial fibrosing lung disease, manifesting as cough, exercise intolerance and ultimately, dyspnea and respiratory failure. It mainly affects West Highland white terriers (WHWTs), lacks curable treatment and has a poor prognosis. Aspiration of gastroesophageal refluxate may play a role in the development of CIPF. In the first part of this study, we completed label-free quantitative proteomic analysis o ...[more]

PMID: 35354473

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