Dataset Information

Class II Immunopeptidome of 9033 cells

ABSTRACT: Cells were treated with either PBS (mock) or hydroxychloroquine (HCQ).

INSTRUMENT(S): Bruker Daltonics timsTOF series

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Suspension Culture

SUBMITTER: Sri Ramarathinam

LAB HEAD: Anthony Wayne Purcell

PROVIDER: PXD029648 | Pride | 2022-02-17

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	10-22-2020_SR-AB-Tims-9033-HCQ_DR_1_10-47-38_Slot2-28_518.d.zip	Other
	10-22-2020_SR-AB-Tims-9033-HCQ_DR_1_10-47-38_Slot2-28_518.mgf	Mgf
	10-22-2020_SR-AB-Tims-9033-HCQ_DR_2_13-31-05_Slot2-29_519.d.zip	Other
	10-22-2020_SR-AB-Tims-9033-HCQ_DR_2_13-31-05_Slot2-29_519.mgf	Mgf
	10-22-2020_SR-AB-Tims-9033-HCQ_DR_3_16-15-16_Slot2-30_520.d.zip	Other

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Publications

Hydroxychloroquine inhibits the mitochondrial antioxidant system in activated T cells.

Kim Man Lyang ML Hardy Melinda Y MY Edgington-Mitchell Laura E LE Ramarathinam Sri H SH Chung Shan Zou SZ Russell Amy K AK Currie Iain I Sleebs Brad E BE Purcell Anthony W AW Tye-Din Jason A JA Wicks Ian P IP

iScience 20211125 12

Although hydroxychloroquine (HCQ) has long been used to treat autoimmune diseases, its mechanism of action remains poorly understood. In CD4 T-cells, we found that a clinically relevant concentration of HCQ inhibited the mitochondrial antioxidant system triggered by TCR crosslinking, leading to increased mitochondrial superoxide, impaired activation-induced autophagic flux, and reduced proliferation of CD4 T-cells. In antigen-presenting cells, HCQ also reduced constitutive activation of the endo ...[more]

PMID: 34934928

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