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Effects of Fusicoccin towards 14-3-3 interactions in IFNa-primed OVCAR3 cells

ABSTRACT: Investigate the effect of Fusicoccin and 14-3-3 interactions in IFNa-primed OVCAR3 cells

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Breast Cancer Cell, Ovary Cancer Cell

SUBMITTER: Farnusch Kaschani

LAB HEAD: Farnusch Kaschani

PROVIDER: PXD030178 | Pride | 2025-02-04

REPOSITORIES: pride

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			Action	DRS
	ACE_0486_AB01.raw	Raw
	ACE_0486_AB02.raw	Raw
	ACE_0486_AB03.raw	Raw
	ACE_0486_AB04.raw	Raw
	ACE_0486_AB05.raw	Raw

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Publications

IFNα primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization.

Andlovic Blaž B Heilmann Geronimo G Ninck Sabrina S Andrei Sebastian A SA Centorrino Federica F Higuchi Yusuke Y Kato Nobuo N Brunsveld Luc L Arkin Michelle M Menninger Sascha S Choidas Axel A Wolf Alexander A Klebl Bert B Kaschani Farnusch F Kaiser Markus M Eickhoff Jan J Ottmann Christian C

Cell chemical biology 20230501 6

The natural product family of the fusicoccanes (FCs) has been shown to display anti-cancer activity, especially when combined with established therapeutic agents. FCs stabilize 14-3-3 protein-protein interactions (PPIs). Here, we tested combinations of a small library of FCs with interferon α (IFNα) on different cancer cell lines and report a proteomics approach to identify the specific 14-3-3 PPIs that are induced by IFNα and stabilized by FCs in OVCAR-3 cells. Among the identified 14-3-3 targe ...[more]

PMID: 37130519

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