Dataset Information

Proteomic Investigation of the Antibacterial Mechanism of Cefiderocol against Escherichia coli

ABSTRACT: DIA-based quantitative proteomics was applied to analyze the global protein alteration of E. coli from the 0 h (control) and 2 h FDC treated groups

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Escherichia Coli

SUBMITTER: Li Yaxing

LAB HEAD: Gao-Fei Du

PROVIDER: PXD031624 | Pride | 2023-03-11

REPOSITORIES: Pride

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Proteomic Investigation of the Antibacterial Mechanism of Cefiderocol against Escherichia coli.

Du Gao-Fei GF Dong Yu Y Fan Xiaolu X Yin Ankang A Le Yao-Jin YJ Yang Xiao-Yan XY

Microbiology spectrum 20220818 5

This study aimed to investigate the antibacterial mechanism of cefiderocol (CFDC) using data-independent acquisition quantitative proteomics combined with cellular and molecular biological assays. Numerous differentially expressed proteins related to the production of NADH, reduced cofactor flavin adenine dinucleotide (FADH<sub>2</sub>), NADPH and reactive oxygen species (ROS), iron-sulfur cluster binding, and iron ion homeostasis were found to be upregulated by CFDC. Furthermore, parallel react ...[more]

PMID: 35980225

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			Action	DRS
	20210727_175801_ecoli.sne	Other
	Ecoli-PRM-final2.sky	Other
	K1-PRM.raw	Raw
	K1.raw	Raw
	K2-PRM.raw	Raw