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Human Matrix Kidney Stones Proteome

ABSTRACT: Protein composition of human kidney matrix stones by nano-LC-MS/MS.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Kidney

DISEASE(S): Nephrolithiasis

SUBMITTER: Markus Hardt

LAB HEAD: Markus Hardt

PROVIDER: PXD033298 | Pride | 2023-10-24

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	220208_HM-1_SDB_150m_5.mgf	Mgf
	220208_HM-1_SDB_150m_5.raw	Raw
	220210_IY2_SDB_150min_5.mgf	Mgf
	220210_IY2_SDB_150min_5.raw	Raw
	220210_RV1_SDB_150min_5.mgf	Mgf

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1 - 5 of 20

Publications

Organic Matrix Derived from Host-Microbe Interplay Contributes to Pathological Renal Biomineralization.

Bai Yushi Y Wang Yongmei Y Kang Misun M Gabe Claire M CM Srirangapatanam Sudarshan S Edwards Austin A Stoller Marshall M Green Stefan J SJ Aloni Shaul S Tamura Nobumichi N Beniash Elia E Hardt Markus M Ho Sunita P SP

ACS nanoscience Au 20230707 4

Matrix stones are a rare form of kidney stones. They feature a high percentage of hydrogel-like organic matter, and their formation is closely associated with urinary tract infections. Herein, comprehensive materials and biochemical approaches were taken to map the organic-inorganic interface and gather insights into the host-microbe interplay in pathological renal biomineralization. Surgically extracted soft and slimy matrix stones were examined using micro-X-ray computed tomography and various ...[more]

PMID: 37601921

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