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In vivo stress reporters as early biomarkers of the cellular changes associated with progeria

ABSTRACT: Study of progeria reporter mouse model using histology, proteomics and western-blotting.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Florian Weiland

LAB HEAD: Francisco Inesta-Vaquera

PROVIDER: PXD033518 | Pride | 2023-03-11

REPOSITORIES: Pride

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			Action	DRS
	20210103_Mus_musculus_CanonicalIsoforms.fasta	Fasta
	20210104_Total_Proteome_MQ_parameters.xml	Xml
	Francisco_total_proteome_f1.raw	Raw
	Francisco_total_proteome_f10.raw	Raw
	Francisco_total_proteome_f11.raw	Raw

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In vivo stress reporters as early biomarkers of the cellular changes associated with progeria.

Inesta-Vaquera Francisco F Weiland Florian F Henderson Colin J CJ Wolf Charles Roland CR

Journal of cellular and molecular medicine 20221006 21

Age-related diseases account for a high proportion of the total global burden of disease. Despite recent advances in understanding their molecular basis, there is a lack of suitable early biomarkers to test selected compounds and accelerate their translation to clinical trials. We have investigated the utility of in vivo stress reporter systems as surrogate early biomarkers of the degenerative disease progression. We hypothesized that cellular stress observed in models of human degenerative dise ...[more]

PMID: 36201626

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