Proteomics

Dataset Information

0

Hydrophobic-hydration hydrophilic interaction (H3I) capturing intact glycopeptides


ABSTRACT: H3I was adopted to idetify the glycosylation of bovine fetuin, human ACE2 and SARS-CoV-2 S1 proteins. Both N- and O-linked glycopeptides are successfully captured with significant enrichment rate improvements, especially for O-glycopeptides with relatively lower hydrophilicity. The majority of N- and O-glycosylation within SARS-CoV-2 S1 and hACE2 proteins are characterized simultaneously by H3I strategy, including 10 novel O-glycosylation regions with important functions in viral fusion and antibody evasion.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Jing Liu  

LAB HEAD: Jing Liu

PROVIDER: PXD033779 | Pride | 2023-04-06

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
ACE2_Glyco_TC_HCD-1.raw Raw
ACE2_Glyco_TC_HCD-2.raw Raw
ACE2_Glyco_TC_HCD-3.raw Raw
ACE2_Glyco_TG_HCD-1.raw Raw
ACE2_Glyco_TG_HCD-2.raw Raw
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